Alignment of alleles: Channel catfish (Ictalurus punctatus) IGHV4S3

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                                                             M   L   K   S   G   D   S   L   T
  U67443  ,IGHV4S3*01                                                       ATG TTA AAG TCA GGA GAT TCT TTA ACC

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 L   N   C   K   V   S   G   F   S   V   T   D   N   S   Y   A           T   A
  U67443  ,IGHV4S3*01           CTC AAC TGT AAA GTA TCC GGC TTC TCT GTT ACT GAT AAC AGC TAC GCC ... ... ACA GCT

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   A   G   K   P   L   E   W   I   N   H   I   W   G   G   G
  U67443  ,IGHV4S3*01           TGG ATT CGA CAA CCT GCA GGA AAG CCT CTG GAA TGG ATA AAT CAC ATT TGG GGT GGT GGA

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 I   T               Y   H   K   D   S   L   K       S   K   F   S   I   S   K
  U67443  ,IGHV4S3*01           ATT ACT ... ... ... TAT CAT AAA GAT TCT CTA AAA ... AGC AAG TTC AGT ATT TCT AAA

                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   G   S   S   S   T   V   T   L   R   G   Q   N   L   Q   T   E   D   T   A
  U67443  ,IGHV4S3*01           GAC GGG TCC AGC AGC ACG GTG ACT CTG AGA GGA CAG AAT CTG CAG ACA GAA GAC ACA GCT

                                                _CDR3-IMGT__
                                101 102 103 104 105 106 107 
                                 V   Y   C   C   T   G   G
  U67443  ,IGHV4S3*01           GTG TAT TGC TGC ACC GGA GGG    #c
#c: rearranged cDNA

This alignment has been generated with the IMGT/AlleleAlign tool developed by Mehdi Yousfi (31/07/2001)

Created: Friday, 22-Sep-2023 18:26:15 CEST
Author: Nathalie Bosc